Unfortunately, Fediverse apps still have a lot of UX issues compared to their mainstream alternatives. Those will need to be smoothed over for mainstream adoption to take root.
They’re attractive to the tech inclined who are comfortable working around what, to them, is minor clunkiness. Mainstream users have shorter attention spans and are more likely to move on when there’s friction.
Far as the meme is concerned, the only Fediverse equivalent is Loops which is still in closed beta.