My random suggestions right now for stuff I like and is played with mouse would be:
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Rimworld. Almost any top-down PC management or (not too fast paced) strategy game should work, but, I really like the crazy random shit that happens to the characters you're slowly getting to know in Rimworld.
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Almost any of the Zachtronics games, if you like to torture your brain. Open-ended sort-of-engineering puzzles.The bigs ones like Spacechem, Opus Magnum and Shenzhen IO in particular, last call BBS for a bit more variety inside one game. Not Infinifactory, since while it doesn't have any kind of fast paced action it still requires navigating in 3D so mouse only wouldn't work.