this post was submitted on 02 Sep 2023
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A biotech company says it put dopamine-making cells into people’s brains::The experiment to treat Parkinson’s is a critical early test of stem cells’ potential to tackle serious disease.

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[–] bfg9k@lemmy.world 41 points 1 year ago (1 children)

If we can get to a point where I am retired and can get a Joywire like in Rimworld, I am definitely doing it.

[–] Robert7301201@slrpnk.net 9 points 1 year ago (1 children)

I'm glad I'm not the only person to immediately think of the Joywire from RimWorld.

[–] stoicmaverick@lemmy.world 5 points 1 year ago (1 children)

Joywire sounds great and everything, but have you ever been vindicated in public? Oh man, so much better. Happened to me today.

[–] Quasi@lemmy.world 4 points 1 year ago (1 children)
[–] stoicmaverick@lemmy.world 1 points 1 year ago

Just a work thing at a meeting that I'd been preaching for a while. My direct boss disagreed, but a regional supervisor there acted like my position was the obvious one in front of my boss and team.

[–] z00s@lemmy.world 23 points 1 year ago

Sounds kinda ominous until you read the subheading haha

[–] qooqie@lemmy.world 17 points 1 year ago (3 children)

Oh okay! That’s weird! I am a little hesitant of having any cells injected into my brain tbh

[–] UFO64@lemmy.world 7 points 1 year ago

Right? Let’s see this pass rigorous muster first.

[–] paradiso@lemm.ee 5 points 1 year ago

I'll be a guinea pig

[–] Scubus@sh.itjust.works 3 points 1 year ago

As someone with severe depression, I'd willingly jam a hot poker through one of my eyes and into my brain if I actually thought it'd help

[–] andrei_chiffa@lemmy.world 14 points 1 year ago (1 children)

A) We already don't know how neurons interconnect (eg why infants loose ~ 70% of their neuron connections between 1 and 3 years). B) That's not how dopanime works C) That's not how Parkinson works either

[–] Mr_Dr_Oink@lemmy.world 11 points 1 year ago (1 children)

For the uninitiated, can you elaborate?

Why is this not how it works?

[–] andrei_chiffa@lemmy.world 6 points 1 year ago

Sure.

The problem is that the brain is not a squishy uniform cell mess that just reacts to some chemicals (dopamine/serotonine/...). All of those are neurotransmitters to specific classes of neurons that have a very specific topological position to perform their function.

So if you just throwing in random neurons here and there, they won't do anything. They are not contributing to any pathways.

Serotonin re-uptake inhibitors and dopamine generator drugs (aka opioids) make the signal send by the "correct" neurons that are there stronger, contributing to the desired effect.

The problem with Alzheimers is the death of "correct" neurons, that occurs before Alzheimer is manifested. So just injecting new ones is unlikely to do anything.

Moreover, the neurons don't just live outside brain. They need to be immortalized to live in a Petri dish. And to acheive it, the only way we can go now is to add factors that in the context of human organism are considered as cancerous.

So it's a combo of "unlikely to be efficient" and "potentially likely to lead to cancer". With Parkinson the tradeoff might be acceptable, but this kind of projects is definitely that raises some red flags for me.

[–] ToxicWaste@lemm.ee 6 points 1 year ago

Soo kinda like the hippies. Just tech instead of chemicals...

[–] ComfyMuffin@lemmy.world 5 points 1 year ago (1 children)

Oh no, that's terrible, where? Where exactly?

[–] Petter1@lemm.ee 4 points 1 year ago

Is this kinda a Lifetime subscription for MDMA?

[–] Mandy@sh.itjust.works 3 points 1 year ago

They had me in the first half ngl

[–] T156@lemmy.world 2 points 1 year ago

If it works, it would be interesting to see if it could also work for people with other forms of brain injury/damage.

Could you use it to help restore function to someone who had a stroke?