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If mirrored microbes require mirrored antibodies to be killed that is something no living thing on earth has the ability to create.
Absolutely. Conversely, if mirrored microbes aren't able to make use of building materials in hosts that are mirrors to them, pathogenicity makes little biological sense (microbes don't make us sick out of spite). Now, if they could, that would be a problem. Even if not, they could fatally disrupt the gut microbiome.
The scope of what I suspect to be the greater danger, I've, perhaps understated. Suppose mirror bacteria "escape" and are able to thrive in the surrounding environment. As you note, known life has not evolved to be able to defend against it. This introduces the possibility of the artificial bacteria displacing the natural ones. Since the biosphere involves more complex organisms feeding on the smaller ones, it is plausible that the entire food web could be disrupted, leading to extinction of extant complex life, unless adaptation occurs quick enough.
What?
Fire, alcohol, bleach, etc. Would all still disinfect.
Immune systems would still work. They detect anything "foreign". Immune system reacts to a metal splinter just like it would for wood or a parasite.
I don't think that's how it works. This would just double the amount of microbes that can possibly exist in the world. Your immune system would still be good, but it would double the number of fronts in the proverbial war.