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I mean this whole thought experiment is based on hypotheticals in the first place. I never go anywhere completely unarmed and with my knife that I always carry I could absolutely kill many coyotes.

Many people also conceal carry which would probably change the matchup to something much larger like a wild cat. I know handgun calibers generally only serve to piss off large game like bears and moose so it would probably top out somewhere around a mountain lion if we are allowing what some of us normally daily carry.