I switch between pc and my steam deck to play Diablo 4. I like it very much and when I use one or the other I'm very quickly adjusted to the different use.

On PC I move my skills to asdf, potion on g. I used to use the spacebar for forced standstill, but now use it for dodge. This way I can keep my hand on the keyboard for doing most things in the game.

Middle mouse button to open inventory, side button 4 to force and button 5 is for my escape scroll because I play hardcore.

I also made the ingame cursor bigger through settings, so it's easier to track it in busy areas.