The DS had plenty of fantastic games, but when it comes to a game I feel had the most beautiful example of using the controls in a creative way, I'd say The World Ends With You takes the cake.

I've literally never played a game that needed such a high degree of multitasking, not just for mental multitasking, but also hand-eye coordination. Playing that game on Hard mode felt crazy, and I literally never unlocked Master mode. Balancing between the top and bottom screen characters was such a challenge, especially if you're actually trying to make use of the green puck for more damage. The fact that each partner has their own battle method is fantastic too, as you never get too comfortable with one character until you finish the game.

Add in fantastic art design, catchy soundtrack, funny & memorable main cast, and you get absolute peak. I can't believe Square let that game rot for more than a decade. The Neo TWEWY sequel was pretty good too, but nothing will literally ever compare to the original's controls. It's just so addicting man.