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Over a quarter of Lemmy users use Sync (based on a poll)
(loot.buckodr.ink)
I did a poll and nearly 30% of the people who voted said they used Sync! It's stayed around that percent the whole time too!
EDIT: Here is the poll I forgot to put this here like five times lol https://strawpoll.com/wby5A21R1yA
There's a big difference which is that clients have minimal lock in. Reddit has a monopoly over the community while you can easily switch clients with little lost.
But switching clients means wasting your time learning a different app and getting used to different UI. I wouldn't like to switch from Connect at this point even though it's a bit buggy so I think client does matter a lot. Reddit APIcalypse was all about clients and if I didn't care about the client I would still use Reddit with RedReader. Or if I cared even less I would use Reddit app.
FOSS doesn't solve the need to occasionally switch clients. FOSS is sometimes abandoned or something better comes along.