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The WHO is about to declare aspartame can cause cancer
(www.vox.com)
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The Roman's used to add lead acetate to their wines to make them sweet. There's records of people at the time noting that drinking to much of this lead sweented wine seems to cause issues. So humanity has known that lead isn't necessarily a good thing for the human body for a very long time.
Yep. They also used mercury to refine gold, and just accepted that gold mine slaves died a lot for some reason. There was no Roman labs doing actual toxicity testing, though, and definitely no Roman FDA.