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It's at least plausible. A decade before Haida Gwaii was first seen by European explorers there was the 1763 Siege of Fort Pitt. During the siege the British famously attempted to infect the natives with smallpox by giving them blankets that had been used by smallpox patients. Whether it worked or not is a subject of debate, but the Europeans clearly had the idea that they could intentionally spread a disease to harm a population.
yeah seems like pasteur just solidified germs as the source sorta like with atoms and dna and such. the ideas were there but not fleshed out. https://en.wikipedia.org/wiki/Germ_theory_of_disease#The_Middle_Ages