When a long-term memory forms, some brain cells experience a rush of electrical activity so strong that it snaps their DNA. Then, an inflammatory response kicks in, repairing this damage and helping to cement the memory, a study in mice shows.
The findings, published on 27 March in Nature1, are “extremely exciting”, says Li-Huei Tsai, a neurobiologist at the Massachusetts Institute of Technology in Cambridge who was not involved in the work. They contribute to the picture that forming memories is a “risky business”, she says. Normally, breaks in both strands of the double helix DNA molecule are associated with diseases including cancer. But in this case, the DNA damage-and-repair cycle offers one explanation for how memories might form and last.
It also suggests a tantalizing possibility: this cycle might be faulty in people with neurodegenerative diseases such as Alzheimer’s, causing a build-up of errors in a neuron’s DNA, says study co-author Jelena Radulovic, a neuroscientist at the Albert Einstein College of Medicine in New York City.
Life is so fucking wild. Like how the hell many weird mutations had to happen for this to work and not result in instant death?
An uncountable number. Billions and billions of simple multicellular organisms reproducing, until one (or some) of them develop this mechanism and use it to drastically increase their survival and chance at reproduction.
It makes me wonder at what stage of evolution it appeared. I'm thinking the simple wormlike animals of the early Cambrian era.
Probably none. Neurons are destroyed all the time.