this post was submitted on 30 Apr 2024
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I'm pretty sure there's a shiny bead in your brain that regulates your temperature. Keep in mind, all my knowledge on this subject comes from Osmosis Jones.
AFAIK (undergrad biology), immune cells release signal molecules that cause temperature increase, more or less localized and wholly independent from the nervous system.
The reason you experience the chills when you spike a fever is the brain sets the desired temperature higher and as a result you perceive cold at your current body temperature. And also why you feel like you are in a sauna when your fever breaks, because the inverse is true.
To be clear this set point does mean induction of peripheral actions to actually elevate the temperature, but the central component of this symphony is the hypothalamus.
There is a lot of uncertainty around fever signaling, here is a great summary of what we know.
You like this chain, Jones?
I concur!
~~Closest thing I can think of is~~ https://en.wikipedia.org/wiki/Brainstem.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034117/
~~The body may act intelligently.. But not directly most related to the brain.~~
Edit: https://en.m.wikipedia.org/wiki/Fever#Pathophysiology_of_fever_induction
And now the only thing I can think of is https://youtu.be/snO68aJTOpM