133
submitted 1 year ago by silence7@slrpnk.net to c/climate@slrpnk.net
you are viewing a single comment's thread
view the rest of the comments
[-] perestroika@slrpnk.net 7 points 1 year ago* (last edited 1 year ago)

The Wikipedia article is perhaps more helpful than the news story.

Fungi are much closer to animals in evolutionary terms than bacteria. Many substances which effectively kill fungi are harmful to animals, including humans. Antibacterial antibiotics are mostly useless. There exist antifungal antibiotics, but their selection is limited. Vaccination is possible, but not yet feasible in people. A mouse has been successfully vaccinated against Candida auris and gained some protection.

Fungal diseases are generally slower compared to viral (very fast) and bacterial (fast) diseases, but harder to wipe out.

This fungus is generally a threat in hospitals, where people with compromised immune systems and open wounds may be encountered. A description of a Candida outbreak in a medical setting can be found here. It broke out in the intensive care unit of a London hospital. Many patients had wounds, catheters or intravenous lines. They resorted to isolating every patient, disinfecting rooms with agressive substances, using plentiful chrorhexidine to prevent infection via wounds and lines, and antifungals to treat patients.

Nobody died at the Royal Brompton Hospital, but the mess was severe. Candidasis of the blood (typically after entry through a wound) has a high level of mortality. Whether it is a case fatality ratio or infection fatality ratio - no idea. With new diseases, one typically learns the CFR first and IFR much later, except in hospitals where you can test every person.

Next year, the US CDC described it as a "catastrophic threat". Antifungals that target Candida with less side effects, and a vaccine against it, are highly sought after. I trust they will be found, but not soon - this is not COVID, it spreads slowly, so everyone isn't running (yet) to put a lid on it.

The hypothesis about how it crossed to humans, is summarized by this picture. Wetlands -> thermotolerance -> birds -> agricultural setting -> humans -> hospital setting. I'm not sure if this guess is correct, but it has explanatory value.

Apparently it was capable of crossing species barriers anyway, because it's a generic sort of decomposer fungus - it needs nothing highly specific, and breaks down a variety of biomolecules for food. What is notable: it gained resistance to antifungals before entering people. Probably through agricultural use.

this post was submitted on 28 Jul 2023
133 points (98.5% liked)

Climate - truthful information about climate, related activism and politics.

5184 readers
443 users here now

Discussion of climate, how it is changing, activism around that, the politics, and the energy systems change we need in order to stabilize things.

As a starting point, the burning of fossil fuels, and to a lesser extent deforestation and release of methane are responsible for the warming in recent decades: Graph of temperature as observed with significant warming, and simulated without added greenhouse gases and other anthropogentic changes, which shows no significant warming

How much each change to the atmosphere has warmed the world: IPCC AR6 Figure 2 - Thee bar charts: first chart: how much each gas has warmed the world.  About 1C of total warming.  Second chart:  about 1.5C of total warming from well-mixed greenhouse gases, offset by 0.4C of cooling from aerosols and negligible influence from changes to solar output, volcanoes, and internal variability.  Third chart: about 1.25C of warming from CO2, 0.5C from methane, and a bunch more in small quantities from other gases.  About 0.5C of cooling with large error bars from SO2.

Recommended actions to cut greenhouse gas emissions in the near future:

Anti-science, inactivism, and unsupported conspiracy theories are not ok here.

founded 1 year ago
MODERATORS