this post was submitted on 03 Aug 2023
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[–] autotldr@lemmings.world 29 points 1 year ago

This is the best summary I could come up with:


A "cancer-killing pill" has appeared to "annihilate" solid tumours in early research - leaving healthy cells unaffected.

Professor Linda Malkas, who has been developing the drug, explained: "PCNA is like a major airline terminal hub containing multiple plane gates.

"Our cancer-killing pill is like a snowstorm that closes a key airline hub, shutting down all flights in and out only in planes carrying cancer cells."

While initial results are promising, the research so far has only concluded that AOH1996 can suppress tumour growth in cell and animal models - with the first phase of a clinical trial in humans now under way.

The pill has been shown to be effective in treating cells derived from breast, prostate, brain, ovarian, cervical, skin and lung cancers.

PCNA had previously been labelled as "undruggable" - and it is hoped the breakthrough could lead to more personalised, targeted medicines for cancer in the future.


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