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Karmic Dice - yes or no?
(bg3.wiki)
I play with it off, because I prefer to not have my rolls messed with in either direction. I don't personally want to play with it giving me an artificial bonus and then likely dumping on me the next time I roll.
As someone else stated, if you don't know what you're doing keep it on for the sake of gameplay. Otherwise turn it off if you don't want it
Baldur’s Gate 3 is a story-rich, party-based RPG set in the universe of Dungeons & Dragons, where your choices shape a tale of fellowship and betrayal, survival and sacrifice, and the lure of absolute power. (Website)
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