Night in the Woods
One of the three protagonists in Day of the Tentacle is female, tho one could argue that Bernard is sort of the primary protagonist.
Sonic Origins Plus lets you play as Amy Rose, as well as the upcoming Sonic Superstars
Lollipop Chainsaw
The Metroid series
Ms. Pac-Man, quite possibly the OG female protagonist
As someone who is working as an Azure and M365 admin for a living... yeah, nah, Microsoft. Nah.
I am glad I already made the jump to Linux at home, and frankly, I think Microsoft would be a fool if they pulled through with this.
I bet they'd revert the decision of making Windows cloud-only within a year.