C4d

I haven't built a gaming PC for over fifteen years; I defected to PlayStation in '08 when the constant upgrading got too expensive to really justify, but now I'm looking to come crawling back.

I am finding it easy enough to find build ideas for very capable (and expensive) machines but I am that out of touch with "what's good" that I no longer have any idea of what would be "good enough" (to play most modern games at "high" settings and at 60fps).

Basically, I would like help in avoiding an attempt at going back to my old ways and building some kind of pie in the sky setup like this:

CPU AMD Ryzen 9 7950X3D

CPU fan NZXT Kraken 360 RGB

MB Asus Prime X670E-Pro WiFi 6E

GPU Gigabyte Aero GeForce RTX 4090 24GB

RAM G.Skill Trident Z5 RGB Series 64GB DDR5-6000

SSD Samsung 990 Pro 2TB

PSU Corsair RM1000x Shift 1000 W

Perhaps the could serve as a starting point - what could you cut from the above build and what would you substitute?

Abstract

As our planet warms, a critical research question is when and where temperatures will exceed the limits of what the human body can tolerate. Past modeling efforts have investigated the 35°C wet-bulb threshold, proposed as a theoretical upper limit to survivability taking into account physiological and behavioral adaptation. Here, we conduct an extreme value theory analysis of weather station observations and climate model projections to investigate the emergence of an empirically supported heat compensability limit. We show that the hottest parts of the world already experience these heat extremes on a limited basis and that under moderate continued warming parts of every continent, except Antarctica, will see a rapid increase in their extent and frequency. To conclude, we discuss the consequences of the emergence of this noncompensable heat and the need for incorporating different critical thermal limits into heat adaptation planning.

Zhao J, Xu L, Sun J, et al Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019 BMJ Oncology 2023;2:e000049. doi: 10.1136/bmjonc-2023-000049

Abstract

Objective This study aimed to explore the global burden of early-onset cancer based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid.

Methods and analysis Incidence, deaths, disability-adjusted life years (DALYs) and risk factors for 29 early-onset cancer groups were obtained from GBD.

Results Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% between 1990 and 2019. Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle Sociodemographic Index (SDI) regions had the highest burden of early-onset cancer. The morbidity of early-onset cancer increased with the SDI, and the mortality rate decreased considerably when SDI increased from 0.7 to 1. The projections indicated that the global number of incidence and deaths of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in fruits, high in sodium and low in milk, etc), alcohol consumption and tobacco use are the main risk factors underlying early-onset cancers.

Conclusion Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex and cancer types. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden