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Magic mushrooms, or any other psychedelic stuff. I did it three times, and in retrospect I'm not sure if I realized what I was messing with. Unlike being drunk, it actually feels like these instances actually changed me as a person. Not for the worse, but it's still kinda spooky.
On the surface it was just some fun, my brain was being silly and everything felt much more vibrant. But beyond that it actually changed my views on people and concepts. It altered my relationships and ultimately who I am as a person. Looking back, thos stuff seems to put your brain into an entirely different mode of creating and removing connections. It's not just messing with the "RAM" like alcohol, this stuff is writing to disk and making persistent changes.
All the above is true. My own few experiences made me more curious, analytical, and open minded. All very good permanent changes.