this post was submitted on 01 Jun 2025
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ADHD
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Doesn't seem to be that much evidence, but I'm in the mood for a new supplement obsession - on it!
I looked back through my NIH history and you're right about the sparse evidence for ADHD, actually. Looks like my interest in NAC, in addition to weaning off THC, came from the bipolar and autism angle, its ability to act a a lead chelator, as well as some tentative dots I connected between its glutamatergic effects and some reading into a mutation of the MC1R gene as passed down to me by my red-head mother.
Likely also conflated my more recent readings into the guanfacine+NAC combo for my brain fog and sleep issues and misremembered my findings from the initial research. Good catch, and an excellent example of 'don't listen to the internet dude.'
Here are some starting points
NAC https://pmc.ncbi.nlm.nih.gov/articles/PMC8211525 - NAC review
https://www.sciencedirect.com/science/article/pii/S0149763415001190
https://pubmed.ncbi.nlm.nih.gov/35316513/
NAC+Guanfacine https://pmc.ncbi.nlm.nih.gov/articles/PMC10960163