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Researchers isolate a pig's brain from it's body, keeping it alive and functioning for several hours
(www.popularmechanics.com)
this post was submitted on 01 Feb 2024
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I wonder if that has implications for drug application... from my memory I believe a common challenge for brain diseases is that most drugs cannot cross the BBB, but if they've made a bypass...
It's a blood vessel bypass to the whole brain, the BBB is between blood vessels inside the brain and brain tissue.
The implication for drugs, is in drug research: normally a drug will get spread all over the body, particularly passing through the liver, which metabolizes all it can, followed by the kidneys, which piss out all they can... so it isn't easy to estimate how much of a given drug actually gets to the brain.
With a bypass, they can inject drugs directly into the brain, and see how they work without "interference" from the rest of the body.