this post was submitted on 21 Jan 2025
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Science

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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[–] Gullible@sh.itjust.works 61 points 2 months ago (1 children)

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[–] nooneescapesthelaw@mander.xyz 7 points 2 months ago (1 children)

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn't know?

[–] scarabic@lemmy.world 7 points 2 months ago (1 children)

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

[–] nomy@lemmy.zip 3 points 2 months ago

Like a lil cashew down there.

[–] RobotToaster@mander.xyz 42 points 2 months ago (1 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] __nobodynowhere@lemm.ee 7 points 2 months ago (2 children)
[–] rickyrigatoni@lemm.ee 28 points 2 months ago

The hat man cleans your brain for you.

[–] RobotToaster@mander.xyz 8 points 2 months ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[–] flicker@lemmy.dbzer0.com 27 points 2 months ago (2 children)

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[–] pelespirit@sh.itjust.works 9 points 2 months ago

Be careful about assuming that your drugs are what they're talking about. Yours sound like they're balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

[–] ChadMcTruth@lemmy.world -2 points 2 months ago

you probably just need fresh nutrients

[–] anarchrist@lemmy.dbzer0.com 15 points 2 months ago (1 children)

I wonder if ketamine has the same effect, he asked apropos of nothing...

[–] metaStatic@kbin.earth 12 points 2 months ago (1 children)
[–] MossyFeathers@pawb.social 12 points 2 months ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[–] workerONE@lemmy.world 11 points 2 months ago (3 children)
[–] Agent641@lemmy.world 6 points 2 months ago (1 children)
[–] rosa666parks@lemmy.dbzer0.com 2 points 2 months ago (1 children)

Then gets you really sleepy

[–] sunzu2@thebrainbin.org -1 points 2 months ago

Being knocked out is not sleep.

[–] TypicalHog@lemm.ee 3 points 2 months ago

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

[–] sunzu2@thebrainbin.org 0 points 2 months ago (1 children)

Se thing as any other substance

Weed too

[–] workerONE@lemmy.world 1 points 2 months ago (1 children)
[–] sunzu2@thebrainbin.org 0 points 2 months ago

That shit don't last long enough?

[–] sunzu2@thebrainbin.org 9 points 2 months ago (1 children)

Alcohol and weed does the same thing, just because you are out. Doesn't mean you are sleeping.

Good to see this common sense being confirmed

[–] otp@sh.itjust.works 1 points 2 months ago

I wouldn't even call it common sense. I remember being taught like 20 years ago that we don't even know for sure why we need to sleep (aside from the fact that we get tired and sleep is pretty good at helping with that).

[–] peoplebeproblems@midwest.social 7 points 2 months ago (2 children)
[–] RvTV95XBeo@sh.itjust.works 7 points 2 months ago

That usually helps me sleep better too

[–] scarabic@lemmy.world -1 points 2 months ago
[–] some_guy@lemmy.sdf.org 6 points 2 months ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[–] TacoButtPlug@sh.itjust.works 5 points 2 months ago (2 children)

I wonder what melatonin does

[–] TypicalHog@lemm.ee 5 points 2 months ago (1 children)

It's a natural hormone brain produces that signals to the body that it's zzz time.

[–] TacoButtPlug@sh.itjust.works 2 points 2 months ago (1 children)

I love it for bedtime and it helps my autoimmune shit. Glad it's not brain bad.

[–] otp@sh.itjust.works 2 points 2 months ago

Aside from possibly becoming a dependency, I'd imagine it doesn't interfere with sleep quality. It's what builds up in your body to make you sleepy/fall asleep.

Too much might keep you groggy in the morning though.

[–] Agent641@lemmy.world 5 points 2 months ago (2 children)

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[–] SirQuackTheDuck@lemmy.world 9 points 2 months ago

Probably just stick to the side of your head.

Have you tried eating the cheese instead?

[–] TacoButtPlug@sh.itjust.works 4 points 2 months ago (1 children)

Charlie Kelly... who taught you about Lemmy?

[–] DaCrazyJamez@sh.itjust.works 2 points 2 months ago

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain...

[–] intensely_human@lemm.ee 5 points 2 months ago

If you want your brain to clean out waste at night, you need to be taking sweeping pills.

[–] Hackworth@lemmy.world 4 points 2 months ago* (last edited 2 months ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[–] Cephalotrocity@biglemmowski.win 2 points 2 months ago (1 children)

Apparently the water supply in my town is dosed with sleeping pills.

[–] pelespirit@sh.itjust.works 9 points 2 months ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater