Honestly if you can already touchtype an ortho isn't going to be that big a learning curve. At least for me (going to an ortho with strong stagger), it finally meant that the keys felt like they were in the right place. I don't think the benefits of other layouts are quite as big if the keyboard actually fits your bone structure.
If you are going to a cut size layout, it's better to add in features incrementally onto something you already know rather than having to learn colemak and layers and thumb clusters.
If you have the time of course to re-learn how to type sure, do it all at once, but any time you spend on another layout (like, say, in the office) is going to make the transition harder. And as I said, layouts designed to make typing on a normal keyboard better make less sense on an ergo.