427
submitted 2 months ago by Don_Dickle@lemmy.world to c/til@lemmy.world
top 50 comments
sorted by: hot top controversial new old
[-] RobotToaster@mander.xyz 129 points 2 months ago

I'll add that to the list of genes I want knocked out when CRISPR gets good enough.

[-] _stranger_@lemmy.world 16 points 2 months ago

Eh, it's probably good enough for this. Go for it.

[-] Eiri@lemmy.world 9 points 2 months ago

We can do this on isolated cells, but I really don't think we have a way to distribute such a change across the zillions of cells in a human body.

And even if we could, it's not clear how much effect altering the gene after the fact would have. Maybe once your apocrine glands have obeyed the gene and developed a certain way, it's too late.

That said... Sign me the hell up.

[-] umbrella@lemmy.ml 6 points 2 months ago* (last edited 2 months ago)

isnt crispr itself the way to distribute it?

[-] Eiri@lemmy.world 10 points 2 months ago

CRISPR makes gene editing easier, but unless you've got a way to deliver it to every cell, it won't do much unless you're targeting such a small number of cells that it's realistic to have a technician physically inject it into a cell.

That would work for an embryo. Ignoring the plethora of ethical issues and the lack of data on long-term effects, it would probably be pretty easy for a scientist to make the change in an embryo and then go through the normal in-vitro fertilization procedure.

For a whole organism, though, it's more difficult. One obvious solution is a specially modified virus, and that's under research.

There's a lot of stuff here if you want to dive deep:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356196/#sec3-biomolecules-10-00839title

load more comments (2 replies)
load more comments (1 replies)
load more comments (1 replies)
[-] dohpaz42@lemmy.world 81 points 2 months ago

Life pro tip for those who do stink when they sweat:

If you ever find yourself in a pinch, and either you forgot deodorant or it wore off (it’s bullshit that these deodorants last 24+ hours), you can use hand sanitizer as makeshift deodorant. The isopropyl alcohol in the hand sanitizer will also kill the bacteria that breaks down those lipids that cause the odor. You can also substitute rubbing alcohol for deodorant and it generally lasts longer.

[-] Nomecks@lemmy.ca 70 points 2 months ago

Can I just rub some Asian people on me?

[-] skizzles@lemmy.ml 46 points 2 months ago
[-] djsaskdja@reddthat.com 8 points 2 months ago

Sure, if they let your smelly ass get close enough to them.

[-] dream_weasel@sh.itjust.works 20 points 2 months ago* (last edited 2 months ago)

The pro tip that we had to give out in college for the newcomers to the ballroom team every semester to mitigate body odor (edit: done in exactly this order):

  1. Shower with soap.
  2. Apply deodorant with antiperspirant.
  3. Put on clean clothes.

You would be surprised how many people in college don't understand the nuances of these points. Or other basically accepted hygiene practices of the area. For example, cologne or perfume is not "deodorant". Also, most things are not clean after you wear them (esp if you sweat), and dont become clean again until they are laundered. You may also notice we had to specify "with soap" for a shower.

The bit about antiperspirant is not strictly necessary, but nobody wants to put their hand near or accidentally in a sweaty pit.

load more comments (6 replies)
[-] BeatTakeshi@lemmy.world 79 points 2 months ago* (last edited 2 months ago)

✋dysfunction?

👉enhancement

[-] AnarchistArtificer@slrpnk.net 40 points 2 months ago

In a genetic sense, it is a dysfunction of the gene that causes this. It's neat because we can actually trace the history of human migrations by looking at the distribution of this particular allele (version of a gene). We have analysed DNA from ancient remains of early Europeans and found that the A allele is absent. It appears like this version of the gene first emerged in an ancient East Asian population.

This gene also determines whether you have dry or sticky ear wax. It's a neat gene because it's uncommon for physical human traits to be controlled by one gene — most human characteristics are controlled by multiple genes (polygenic traits); ginger hair is another example of a monogenic trait. ABCC11 is neat because it affects multiple traits: sweat smell and earwax dryness.

It might also be implicated in breast cancer risk (I can't tell whether that's in an increased risk or decreased risk), but we don't really understand yet how that would work. From skimming the research, I would say we generally don't understand how this gene works at all. We do know some stuff about it and how/why it works, but we're still a decent way off of actually understanding its implications.

load more comments (6 replies)
[-] BackOnMyBS@lemmy.autism.place 57 points 2 months ago

I'm not comfortable with calling something that is prevalent in 80%-95% of an area's population a dysfunction unless it results in remarkably lower life expectancy or quality of life otherwise.

[-] ArbitraryValue@sh.itjust.works 101 points 2 months ago* (last edited 2 months ago)

The condition is caused by a loss-of-function mutation. It's a statement about a protein, not about the whole person.

Edit: ChatGPT explains it better than I can.

The ABCC11 gene encodes an apical efflux pump that helps transport fatty compounds, or lipids, from cells into sweat. When the gene is non-functional, these lipids can't cross the membrane barrier to reach the armpit. This prevents bacteria from accessing and metabolizing the organic compounds in sweat, which in turn reduces the production of odorant substances.

But are there negative ramifications of this mutation?

[-] ArbitraryValue@sh.itjust.works 8 points 2 months ago* (last edited 2 months ago)

I'm not aware of any negative ramifications, but the naming is not a matter of ramifications. This isn't just an abstract change from more body odor to less body odor. Proteins are machines, there's a particular protein machine for moving certain molecules out of cells and into sweat, and in people with this mutation that machine doesn't work. Consider an analogy to a light switch. It's not a toggle between "emit brightness" and "emit darkness". There's a machine on the ceiling for converting electrical energy into light. When the switch is in one position that machine is functioning, and when the switch is in the other position the machine is not functioning. In other words, darkness isn't an alternate way for the machine to function, but rather the consequence of the machine not functioning.

The lightbulb analogy isn't perfect because you could say that the switch and lightbulb together are the machine, and that the function of this machine includes the capability to switch on and off in response to a signal. There are many proteins that can also be switched on or off and they're not "nonfunctional" even when they're "not functioning". However, this mutation doesn't create a protein that can be switched on and off, so I suppose you can think of it like smashing a light which you can't control with a switch. Maybe the light was annoying and you're happier without it, but you still broke it.

load more comments (4 replies)
load more comments (6 replies)
[-] John_CalebBradberton@lemmy.world 6 points 2 months ago

This is a good point.

load more comments (1 replies)
[-] taiyang@lemmy.world 51 points 2 months ago

Is this specificly East Asian? Cause I had an Indian roommate once and that dude could knock out half the city with his stretch.

[-] dream_weasel@sh.itjust.works 15 points 2 months ago

Yes. It is. The article specifically calls out east asia.

load more comments (1 replies)
[-] DragonTypeWyvern@midwest.social 12 points 2 months ago

A lot of that is diet and, of course, hygiene. Having 10% less BO doesn't do anything for you if you're not showering, or eating garlic gloves whole.

load more comments (1 replies)
[-] ikidd@lemmy.world 7 points 2 months ago

Yah, wow, some Indians need to have some intervention done. I know plenty of Indians that are perfectly fine, and then there's a subset that smell like me after a 2 week solo backpacking trip.

[-] radix@lemm.ee 35 points 2 months ago* (last edited 2 months ago)

I'm East Asian. My ex (also Asian) said I smelled bad sometimes after exercising, but my current partner (not Asian) says I don't have any body odor. I do think that when we go to the gym together, their smell far outweighs mine. I can't smell myself at all, but then again, people are usually habituated to their own scents.

Sometimes, though, when I was a child, my father would come home from the gym, and we could all smell him from a mile away. I don't know if that's because the gene skipped him or if it's just because humans generally think their close family members are stinky.

It's nice to talk about this when my armpits aren't in danger of being sniffed by several drunk friends.

[-] partial_accumen@lemmy.world 20 points 2 months ago

I can’t smell myself at all, but then again, people are usually habituated to their own scents.

Olfactory fatigue

[-] bizarroland@fedia.io 20 points 2 months ago

This is the same reason why people who have cats can't smell the strong cat urine smell of their own home and clothes, or why cigarette smokers have no idea how much their clothes stink.

load more comments (3 replies)
[-] Septimaeus@infosec.pub 6 points 2 months ago

IME no one is immune to gym odors. There are still many fats and proteins secreted by non-apocrine glands that are digestible by bacteria, so to eliminate body odor entirely we would probably need to evolve strong antimicrobial secretions or something.

Sweat rinses much of this bacteria-food off of us, but since we started wearing clothes it just transports the bulk of it to what we’re wearing (now stinky gym clothes).

That’s why showering before a workout is so effective for controlling gym odors: most of the bacteria and its food ends up in the drain rather than your clothes. Showering after is then mostly to rinse off salt.

Anyway I imagine the times you’ve smelled people after the gym were simply the times they skipped that pre-workout shower.

[-] houstoneulers@lemmy.world 31 points 2 months ago

A feature, not a bug

[-] TheAlbatross@lemmy.blahaj.zone 31 points 2 months ago* (last edited 2 months ago)

I bet it would be wild to be unaware of body odor and run into someone without this gene disfunction.

Like whoa you do WHAT when you sweat? Like every time? This is normal? It smells Iike onions, spices and cheese when you work??

[-] Thassodar@lemm.ee 14 points 2 months ago

Onions, yes. Spices and cheese? What?

[-] Gullible@sh.itjust.works 9 points 2 months ago* (last edited 2 months ago)

Men tend to smell of cheese and women onions, respectively. I’d love to know whether transitioning alters one’s scent and whether the person tends to notice the change.

[-] femtech@midwest.social 17 points 2 months ago

Hmmm I smelled of onions before transitioning but my hormones were out of wack before that. I'll ask one of my friends that was a body builder before her transition if she noticed a change.

load more comments (4 replies)
[-] AlligatorBlizzard@sh.itjust.works 9 points 2 months ago

Oh big time. I'm a transgender man and it was very noticable for a while when my body odor changed.

load more comments (1 replies)
[-] RustyShackleford@literature.cafe 11 points 2 months ago

I’ve noticed after a workout a balls scent, but I’ve never thought of onions, spices and cheese.

[-] TheAlbatross@lemmy.blahaj.zone 9 points 2 months ago* (last edited 2 months ago)

I think it's diet dependant. I notice there's a distinct change in my body odor when my diet contains a great deal of onions and spices and a general acrid scent that's somewhat evocative of funky cheese.

What have you been eating lately? 🤭

[-] JusticeForPorygon@lemmy.world 11 points 2 months ago

My dad once told me Curry has that effect and that's why Indian people stink.

He was also kinda racist tho so that might not be true.

load more comments (1 replies)
[-] RustyShackleford@literature.cafe 10 points 2 months ago

It varies, but I eat a lot of vegetables (especially garlic and onions) and chicken. But, I drink a lot of coffee.

[-] AnarchistArtificer@slrpnk.net 6 points 2 months ago

It reminds me of how there is a gene that determines whether eating asparagus makes your pee stink, and there's a different gene that determines whether you can smell it. I had a friend who didn't have the stinky pee gene, but her boyfriend did, and she complained of the smell when she used the bathroom after him occasionally. He had the stinky pee gene, but not the gene to be able to smell the stink.

This came up in a random conversation with my friend, before she knew about the genes thing. I was so excited that I got to tell her about a cool science thing that I couldn't speak for a few moments.

load more comments (2 replies)
[-] JigglySackles@lemmy.world 26 points 2 months ago

Dysfunction ? More liked improved function...can I get the same treatment please?

[-] bighatchester@lemmy.world 7 points 2 months ago

I somehow got this . I never wear deodorant and don't get any BO even after a crazy sweaty day .

[-] Benjaben@lemmy.world 25 points 2 months ago

Just make sure you're getting some outside feedback on that, I've known folks so used to their own "brand" that they just couldn't tell. Smelled utterly rank and couldn't be convinced of it.

[-] ChairmanMeow@programming.dev 12 points 2 months ago

Most people with BO say that.

I know a guy who didn't believe he had BO, and if you were standing next to him you wouldn't notice either. But walk behind him, and suddenly you noticed an awful BO coming off of him.

Always ask someone else if you smell, it's not always noticeable to yourself.

load more comments (2 replies)
[-] saltesc@lemmy.world 12 points 2 months ago

I'll assume east Asians. As you head not too far away from the Pacific, the rest of Asia starts needing deodorant quite badly.

[-] Underwaterbob@lemm.ee 12 points 2 months ago

Try telling that to the 5-20% of the guys at my gym in Korea who are absolutely ripe. The problem with having most of your population not have major BO is that those that do generally have trouble dealing with it.

[-] stoly@lemmy.world 7 points 2 months ago

And some Koreans need no deodorant at all.

load more comments (3 replies)
[-] LeFantome@programming.dev 7 points 2 months ago

Try buying deodorant at a supermarket in South Korea. Impossible.

load more comments (4 replies)
load more comments
view more: next ›
this post was submitted on 26 Aug 2024
427 points (98.6% liked)

Today I Learned

17722 readers
332 users here now

What did you learn today? Share it with us!

We learn something new every day. This is a community dedicated to informing each other and helping to spread knowledge.

The rules for posting and commenting, besides the rules defined here for lemmy.world, are as follows:

Rules (interactive)


Rule 1- All posts must begin with TIL. Linking to a source of info is optional, but highly recommended as it helps to spark discussion.

** Posts must be about an actual fact that you have learned, but it doesn't matter if you learned it today. See Rule 6 for all exceptions.**



Rule 2- Your post subject cannot be illegal or NSFW material.

Your post subject cannot be illegal or NSFW material. You will be warned first, banned second.



Rule 3- Do not seek mental, medical and professional help here.

Do not seek mental, medical and professional help here. Breaking this rule will not get you or your post removed, but it will put you at risk, and possibly in danger.



Rule 4- No self promotion or upvote-farming of any kind.

That's it.



Rule 5- No baiting or sealioning or promoting an agenda.

Posts and comments which, instead of being of an innocuous nature, are specifically intended (based on reports and in the opinion of our crack moderation team) to bait users into ideological wars on charged political topics will be removed and the authors warned - or banned - depending on severity.



Rule 6- Regarding non-TIL posts.

Provided it is about the community itself, you may post non-TIL posts using the [META] tag on your post title.



Rule 7- You can't harass or disturb other members.

If you vocally harass or discriminate against any individual member, you will be removed.

Likewise, if you are a member, sympathiser or a resemblant of a movement that is known to largely hate, mock, discriminate against, and/or want to take lives of a group of people, and you were provably vocal about your hate, then you will be banned on sight.

For further explanation, clarification and feedback about this rule, you may follow this link.



Rule 8- All comments should try to stay relevant to their parent content.



Rule 9- Reposts from other platforms are not allowed.

Let everyone have their own content.



Rule 10- Majority of bots aren't allowed to participate here.

Unless included in our Whitelist for Bots, your bot will not be allowed to participate in this community. To have your bot whitelisted, please contact the moderators for a short review.



Partnered Communities

You can view our partnered communities list by following this link. To partner with our community and be included, you are free to message the moderators or comment on a pinned post.

Community Moderation

For inquiry on becoming a moderator of this community, you may comment on the pinned post of the time, or simply shoot a message to the current moderators.

founded 1 year ago
MODERATORS