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Depressiom is a malfunction of the brain, just like diabetes is of the pancreas. It has both genetic and environmental triggers.
Some people are going to contact the disease early for no apparent reason. They fight it their entire lives.
Other people have strong environmental influences that trigger the disease. The right treatment can effectively stop or even reverse the progression of the disease. Other people are resistant to the treatment the the disease progresses unchecked.
Both diseases are deadly if not treated at all.
The hardest part for people suffering from depression is that the disease itself fights against treatment. All the things that people need to do to feel better are the last things a depress person wants to do: Set a regular sleep cycle, have a strong exercise routine, eat well balanced food, take your medication on time, avoid self-medicating with other drugs, attend therapy regularly, interact with supportive friends, engage in hobbies they enjoy, etc... aka a living hell and a daily battle requiring energy they don't have. Oh and every part treatment takes time to have an effect as well. So at the beginning (2-5 years) they have to do all that work to still feel like shit at the end of the day.