Eric Cartman in particular has done irreperable damage to the western psyche. For all of their faults, the folks at South Park at least attempted to write Eric Cartman as a fucking loser. Unfortunately, the vast majority of people identified with him, because all the traits that made him a loser were seen as admirable.
Kyle went from someone rightfully but indirectly telling white Americans to shut the fuck up into a whiny SJW karen getting offended by epic based Cartman.