This is a partial answer, with possibly some misinformation. Should I just shut my mouth and hope that someone who actually knows what's happening will answer you? Yes. Yes I should. But I'm a bit drunk, so you're just going to have to read my incomplete (and possibly wrong) explanation.

Brianna Wu got famous from gamergate. She got harassed by gamers. I don't remember what for, possibly they thought she slept with someone for good reviews on a game? That or she criticized a game that maybe an ex had worked on. Shit, I dunno, I'm actually absolutely making stuff up. Well, I've come this far, let's keep going! TERFs are certain she's trans, I'm not certain she's trans, but maybe she is? I'm unsure. Not that it matters, she was a woman that gamergate targeted, of that I am certain. She's now just the most annoying lib of all time, but keeps trying to draw on progressive cred from being harassed by gamers during the gamergate era. I suspect she's going to do a "why I left the left" situation, but maybe you don't even have to do that to be a grifter these days.

Long story short, she was harassed during gamergate, she's extremely, unfortunately lib, and it's better if you pay no attention to her twitter takes.