this post was submitted on 31 Mar 2025
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traaaaaaannnnnnnnnns

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Warning: Grapefruit can interact with drugs, such as decreasing the effectiveness of estradiol, making Oxycodone last longer, increasing blood levels when on Viagra, and much more.

Grapefruit inhibits multiple enzymes in the small intestine, most notably CYP3A4. CYP3A4 is involved in the breaking down of a lot of drugs, so when it's inhibited Oxycodone becomes inactive slower, and estradiol won't break down all the way into estrogen. Drugs that are affected by grapefruit will often have warnings on their packaging

Personally, I like putting just a little bit of salt on my grapefruit, to counteract the bitter flavor. Dumping sugar on it doesn't help. Grapefruits are about half as sour as lemons, since they have half the citric acid content.

Grapefruits were accidentally created as a cross between the sweet orange and the pomelo, in Barbados. Those fruits originate from Asia, but were brought to the Caribbean in the 17th century. Since it's parent fruits are native to Asia, it grows well in Asia too.

some-controversy and peekaboo (China and Vietnam) are the two largest producers of Grapefruits, producing collectively 6.3 million tons out of the 9.8 million tons of worldwide production.

The painting was made by Robert Papp, who has a website here: https://robertpapp.com/. I don't really know anything about the guy.

The lemon things with all of the recipes was really cool, but to be honest I just like grapefruit raw, cut in half and ate with a spoon.


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[โ€“] TerminalEncounter@hexbear.net 11 points 2 weeks ago* (last edited 2 weeks ago) (5 children)

I'm in pediatrics, we get treated like a hard poke IV access team (kids veins are smaller and more fragile). I'm fine with it! Happy to help.

We got a call about accessing someone else's IVAD. Now, like, I can do it. I did a bit at a cancer centre. We're a multifunction unit and get plenty of kids with IVADs. But what on earth made you call peds about IVADs? Like, yeah I can help you out but if this adult has one they're probably known to the outpatient department or to the oncology unit here and that's who can sort you out more appropriately. I'm happy to help and I can but I'm just one gal who knows the deal with them, but not everyone here does. Very weird.

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[โ€“] 0x2640@hexbear.net 11 points 2 weeks ago (6 children)
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[โ€“] BountifulEggnog@hexbear.net 11 points 1 week ago (3 children)

Is my hair getting in my mouth going to get better when it gets a bit longer or is this just an issue I have to deal with now? It was kinda cool at first but now its like every time I eat madeline-sadeline

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[โ€“] AshenWolf@hexbear.net 11 points 2 weeks ago

I just realized I missed the day where I've had a hexbear account for a year. So... I've had a hexbear account for a bit over a year. Wow. I think a bit ago I would have said that it felt like it hadn't been so long ago, but now? It feels like I've been here so much longer than a year.

[โ€“] Cadende@hexbear.net 10 points 2 weeks ago (1 children)

all capsI FUCKING LOVE GARAPEFRUIT lets-fucking-go

did not know it interfered with estrogen though that's sad. even with injections?

[โ€“] TerminalEncounter@hexbear.net 10 points 2 weeks ago (3 children)

Estradiol regardless of form gets metabolized by a specific liver enzyme. Some specific part of grapefruit, for reasons known only to god, interferes with that enzyme. So it will mess with your levels. If you have a grapefruit every once in a while, like once a month or less, youll probably be fine.

CBD also interferes with that liver enzyme but since most people stick with whatever their regiment of weed intake before and after HRT, it's kind of baked in - but technically we should be advising no CBD and likely no cannabis in general, but imagine that struggle yeesh. Grapefruit, on the other hand, people don't eat it on the regular and some meds go through the same liver enzyme pathway. So generally, if you are taking any med that is affected by grapefruit you should just skip the grapefruit.

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[โ€“] GayTuckerCarlson@hexbear.net 10 points 2 weeks ago (4 children)

Thank you to everyone who liked the previous mega, I hope I inspired you to make a lemon treat

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[โ€“] BountifulEggnog@hexbear.net 10 points 1 week ago (3 children)

i-think-that if a game lets me adjust my facial hair I should also be able to adjust my boob size

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[โ€“] Thallo@hexbear.net 10 points 2 weeks ago (2 children)

I can't understand how a cross between an orange and a pomelo could be so awful.

[โ€“] AshenWolf@hexbear.net 10 points 2 weeks ago

This is the hottest take of the grapefruit mega

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[โ€“] LocalOaf@hexbear.net 10 points 2 weeks ago

havin' a case of the Gloom today

It's cold and dark and rainy and miserable here and I'm exhausted and sad and don't feel good so I'm just gonna go to bed early and write off the whole day catgirl-flop

[โ€“] Disaster_of_Passion@hexbear.net 10 points 2 weeks ago (1 children)

depresso-posting

I wish "getting better" didn't have to hurt so much. I know rationally that having a decent amount of neutral days, and even very occasionally having a good day, is better than just feeling continuously like the lowest shit day after day after day after day. But at least when I'm constantly broken down I can get kind of numb to it, right now it's like I feel good just enough to not get used to feeling bad, just enough to be constantly hit with this soulcrushing whiplash. Built up just enough that I can break again.

I know it's all part of the process, like building a muscle, it gets torn and heals back stronger bit by bit by bit over time. Just wish that that could get from the part of my brain that knows things to the part of my brain that feels things, just wish that in the meantime I wasn't just some whiny little shit who feels bad about having good days, like what the fuck.

[โ€“] BountifulEggnog@hexbear.net 10 points 2 weeks ago

spoilerYea the whole "trending upward" thing still kinda sucks and I think is where I'm at.

[โ€“] SamotsvetyVIA@hexbear.net 10 points 2 weeks ago (2 children)

please suggest me games like genshin and botw which have good exploration and puzzling

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[โ€“] buh@hexbear.net 10 points 1 week ago

They made an emoji of me ๐Ÿซฉ

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